Dementia is a syndrome, not a disease. ... Dementia is a group of symptoms that affects mental cognitive tasks such as memory and reasoning. Dementia is an umbrella term that Alzheimer's disease can fall under. It can occur due to a variety of con
Dementia is a syndrome and it causes loss of several overlapping intellectual abilities of the brain along with memory loss. Dementia can occur due to several conditions, the most common of dementia is Alzheimer's disease (50-70%). Other types of dementia are - Multiinfarct dementia, Fronto-temporal dementia, Parkinson's disease, normal pressure hydrocephalus, Lewy body dementia, alcoholic dementia, AIDS, drugs, toxins, head injury and brain tumors.
Dementia, basically a term applied to a group of symptoms that negatively impact memory. When we talk about Alzheimer’s is a progressive disease of the brain that slowly causes impairment in memory and cognitive function. The exact cause is unknown to us and no cure is available.
In Alzheimer's disease, initial symptoms are:
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- lack of initiative
- lack of interest in work
- neglect of routine tasks
Then gradually develop forgetfulness in the form of remembering and recalling the name of a person and difficulty in recalling day to day events. The patient may ask the same question repeatedly, having failed to retain the answer.
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Difficulty in:
- Making the judgment
- Performing tasks requiringseveral steps
- Problem-solving are found difficult
- Change in personality and mood
- More commonly depression than agitation
- Sleep disturbance is quite common along with loss of social interaction
- Suspiciousness or frank paranoid behavior is quite troublesome
- The patient may have visuospatial disorientation and may get lost even along habitual routes
- In advance stage, the patient becomes dependent for day to day activities and ultimately become bedbound
- Dementia patients may have variable symptoms mentioned above along with other symptoms according to the underlying cause
In Alzheimer's disease, MRI brain shows disproportionate atrophy of hippocampus and enlargement of the temporal horn of lateral ventricle. SPECT (single-photon emission computed tomography) and PET (positron emission tomography) show diminished activity in the medial temporal lobe and parietal association area. Distinctive microscopic changes in the brain in Alzheimer's disease are- neurofibrillary tangles within nerve cells, neurotic plaque (amorphous material scattered throughout the cerebral cortex) and degeneration of neurons in the hippocampus.
Although symptoms of the two conditions may overlap, distinguishing them is important for management and treatment.
(With inputs from Dr. Jaideep Bansal, Director, and Head of Department, Neurology, Fortis Hospital Shalimar Bagh)
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