The will to lose weight has always been there, but the methods have evolved over time. These days, the word 'Ozempic' is on everyone’s lips and for good reason. Dubbed the ‘miracle weight loss drug’, Ozempic, or semaglutide, was originally developed to manage diabetes. However, its ability to curb appetite and aid in significant weight loss has given it global recognition — though not without raising concerns about potential side effects. One common side effect Ozempic users are reporting is gastrointestinal issues.
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Why Is There So Much Hype Around Ozempic?
In an interaction with the OnlyMyHealth team, Dr Anjana Kalia, Ayurvedic Doctor and Nutritionist at Anjana Kalia’s Diet Clinic, Delhi, shares, "Ozempic (semaglutide) is a medication often prescribed for type 2 diabetes." However, it has gained significant attention due to its weight loss side effects, leading to its widespread use for that purpose, often off-label.
The US Food and Drug Administration (FDA) has approved semaglutide under three different names — Ozempic®, Wegovy®, and Rybelsus® — each designed for a specific health condition, with its own formulation and dosage.
However, it's crucial to understand that Ozempic is primarily intended for managing type 2 diabetes and comes with potential risks and side effects.
How Ozempic (Semaglutide) Affects The Digestive System?
According to Dr Kalia, Ozempic is a GLP-1 receptor agonist that works by mimicking the effects of a natural hormone called glucagon-like peptide-1, which helps regulate blood sugar levels.
“One of its actions is delaying gastric emptying, which means it slows down how quickly food moves from the stomach to the intestines,” she explains. “This helps people feel full longer, aiding in weight loss, but it can also lead to nausea, bloating, or indigestion.”
Additionally, it affects areas of the brain that regulate appetite and nausea, which may contribute to gastrointestinal discomfort in some individuals.
Gastrointestinal Symptoms Of Ozempic To Watch Out For
The most commonly reported gastrointestinal side effects of Ozempic, or semaglutide, include:
- Nausea
- Vomiting
- Diarrhoea
- Constipation
- Abdominal pain
- Bloating
- Loss of appetite
- A feeling of fullness or discomfort after eating even small amounts
Dr Kalia notes that these symptoms tend to occur more frequently during the initial stages of treatment or when the dosage is increased.
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How Can Patients Manage Or Minimise Side Effects?
To manage or minimise side effects, start with a low dose and increase gradually as directed by your doctor, advises Dr Kalia. Other tips include:
- Eating smaller, more frequent meals rather than large meals
- Avoiding greasy, spicy, or very sweet foods to reduce nausea
- Staying well-hydrated
- Including fibre-rich foods can help.
- Taking the injection before bedtime
- Following the prescribed injection technique and not missing doses.
When Should Someone Stop Taking Ozempic?
You should immediately seek medical attention and contact your healthcare provider if you experience severe stomach pain (especially if it radiates to the back), persistent nausea and vomiting, yellowing of the skin or eyes, or if you can’t keep fluids down, says Dr Kalia, adding, “If gastrointestinal symptoms are significantly impacting your daily life despite adjusting your diet and following medical advice, it’s important to consult your doctor.” They may adjust your dosage or explore alternative medications.