Cerebellar hypoplasia is a rare embryonic developmental disorder in which the cerebellum is either missing entirely or is smaller than usual. It may be genetic or occur sporadically. Cerebellar hypoplasia may be caused by thyroid abnormalities, environmental influences such as drugs and chemicals or viral infections or stroke.
Cerebellar hypoplasia may be associated with other disorders including Dandy-Walker syndrome, Werdnig-Hoffmann syndrome and Walker-Warburg syndrome and CASK Gene Mutation. This disorder has also been known to be a symptom of Acutane embryopathy and Meckel syndrome.
The list of signs and symptoms mentioned in various sources for Cerebellar hypoplasia includes the 13 symptoms listed below:
- Delayed development
- Reduced muscle tone
- Mental retardation
- Involuntary eye movements
- Poor balance
- Hearing impairment
- Poor fine motor skills
- Infant feeding problems
There is no standard course of treatment for cerebellar hypoplasia. Treatment is symptomatic and supportive. Balance rehabilitation techniques may benefit those experiencing difficulty with balance. Treatment is based on the underlying disorder and the symptom severity.
The prognosis of cerebellar hypoplasia is dependent upon the underlying disorder. Some of the disorders that are associated with cerebellar hypoplasia are progressive, which means the condition will worsen over time, and will most likely have a poor prognosis. Other disorders that feature cerebellar hypoplasia are not progressive, such as those that are the result of abnormal brain formation during foetal development, and might have a better outcome.
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