
Crossing 40 is a turning point. The body starts giving signals that one never really paid attention to. These signals typically include slower metabolism, stiffness while waking, unexplained fatigue, and mood dips at times. This is also usually the age when you start taking supplements. With the aisles full of options, from calcium, magnesium, omega-3s, multivitamins, and collagen, choosing one that will actually make a difference can be confusing. But what if we tell you that there is one supplement that will help take care of these troubles for you?
So, the editorial team of Onlymyhealth reached out to Dr Rahul Mathur, Department of Internal Medicine, CK Birla Hospitals, Jaipur, and according to him, if you have to choose just one, then the answer is surely Vitamin D3.
"If I have to choose only one supplement after the age of 40, it would be Vitamin D3. After 40, natural Vitamin D production in the skin declines. Most Indians are already deficient because of an indoor lifestyle. Low Vitamin D causes weak bones, fatigue, aches, low immunity, and mood swings. Vitamin D3 improves bone strength, muscle power and helps prevent osteoporosis. It also supports heart health and reduces the risk of falls in older adults,” Dr Mathur explained.
Also Read: Why Magnesium Is Important For Women’s Health - Expert Explains

Why Vitamin D3 Is Important After 40
Here’s why vitamin D3 is the best investment in your health in your 40s:
1. As you get older, your body produces less Vitamin D.
Even if you get regular sunlight, the skin's ability to produce Vitamin D reduces with age. Add long working hours indoors and growing screen time to the mix, and deficiency becomes almost inevitable.
2. Most Indians have a deficiency in Vitamin D already.
Despite abundant sunlight, more than 70 to 80% of Indians are Vitamin D-deficient. This is due to urban lifestyles, sunscreen use, pollution, and limited direct sun exposure.
3. It's not only about bones: Vitamin D3 acts similarly to a hormone.
Vitamin D3 impacts more than 200 bodily processes. It helps your intestines absorb calcium, supports muscle health, protects the heart, and keeps your immune system running smoothly. Low levels can manifest in ways you might not expect:
- Fatigue and low energy
- back pain or aching body
- Frequent infections
- Hair fall
- Mood swings or irritability
Many people chase multiple supplements for these symptoms, when Vitamin D3 deficiency is often the real culprit.
Also Read: What Is The Right Way To Take Supplements? Expert Answers

Why Calcium Alone Won't Work
“People over 40, especially women, often begin taking calcium supplements. But calcium can't do its job without Vitamin D3,” Dr Mathur added. Think of calcium as bricks and Vitamin D3 as the cement. Without Vitamin D3, calcium doesn't reach the bones; it just passes through the body unused. For this reason, deficiency in Vitamin D3 is one of the leading factors for osteopenia, osteoporosis, and increased fracture risk in the elderly.
Strengthens Muscles and Reduces Risk of Falls
Studies have shown that Vitamin D3 increases muscle strength and balance, thereby reducing the risk of falls-one of the leading causes of serious injuries after 50.
Supports Heart and Immunity
Vitamin D3 reduces inflammation, improves blood pressure regulation, and regulates heart health. It also works as an immunity booster, as people who have low Vitamin D are found to fall sick more often.
How to Know If You Should Take a Vitamin D3 Supplement?
Dr Mathur suggested getting a simple Vitamin D blood test, known as 25(OH)D. “If the levels are low, your doctor may prescribe Vitamin D3 in high doses weekly for a few weeks, followed by a daily or weekly maintenance dose,” he shared.
Dr Mathur also advised, “Never start high-dose supplements without medical advice.”
Bottomline
Expert suggests that after 40, Vitamin D3 is one supplement that should be on your daily shelf: It strengthens bones, boosts immunity, helps make your mood and energy levels improve, and supports healthy ageing. If there's only one supplement to invest in, it should be Vitamin D3.
Also watch this video
FAQ
1. Does Vitamin D3 synthesise adequately just with sunlight after age 40?
Not usually. With age, the skin's capability to synthesise Vitamin D diminishes, so supplements are significant.2. Do Vitamin D3 supplements improve fatigue and mood?
Yes, low Vitamin D3 is associated with fatigue and mood swings. Many times, the correction of a deficiency improves energy and mood stability.3. How soon does vitamin D3 work?
Most people begin noticing changes within four to six weeks of consistent supplementation, when energy improves and the muscle aches lessen.
How we keep this article up to date:
We work with experts and keep a close eye on the latest in health and wellness. Whenever there is a new research or helpful information, we update our articles with accurate and useful advice.
Current Version
Nov 08, 2025 00:40 IST
Published By : Tanya Srivastava