Research Approves Antibiotics As First Line Treatment For Appendictis

According to a recent research, antibiotics can be used as a treatment method for appendicitis. Read on to know more. 

Navya Kharbanda
Written by: Navya KharbandaPublished at: Nov 02, 2021
Research Approves Antibiotics As First Line Treatment For Appendictis

There was a research conducted to know about the effectiveness of antibiotics in treating appendictis. According to the concluding results of the Comparing Outcomes of antibiotic Drugs and Appendectomy (CODA) trial, and the treatment guideline for appendicitis by the American College of Surgeons, antibiotics can now be accepted first line treatment method for most of the patients with appendicitis. The results of this study were published in the 'New England Journal of Medicine'. Keep reading to know more about the antibiotics and appendicitis research. 

Dr David Flum, co-principal investigator and professor and associate chair of surgery at the University of Washington (UW) School of Medicine, said, "In the first three months after taking antibiotics for the condition, nearly 7 in 10 patients in the antibiotic group avoided an appendectomy. By four years, just under 50 per cent had the surgery." He further added, "Other outcomes favoured either antibiotics or surgery. Putting it all together, antibiotics look to be the right treatment for many, but probably not all, patients with appendicitis."


CODA is the largest random clinical trial of appendicitis treatment. A total of 25 hospitals in 14 states, 1,552 patients with appendicitis aggreed to participate and were randomised to get antibiotics or to go through an appendectomy. "While there were advantages and disadvantages to each treatment, we found that both treatments are safe, and patients will likely value these outcomes differ based on their unique symptoms, concerns and circumstances," Dr. Flum said.

Also read: What Is Appendicitis? Here Are Its Signs, Causes And Treatment

Dr. Giana Davidson said that after looking at the study results and updated treatment guidelines, it is important for surgeons and patients to talk about the advantages and disadvantages of both surgery and antibiotics before deciding on what treatment is the best for that individual at that time. She is a UW associate professor of surgery and director of the CODA trial's clinical coordinating centre. "In an emergency setting, patients with appendicitis can make a treatment decision hurriedly," Davidson added. 

Takeaway points: 

  • Antibiotics can be used as first line treatment for appendicitis 
  • Not all patients can be treated through antibiotics as surgery is neccesary in some cases
  • There are advantages and disadvantages to each treatment 
  • Both treatment options are safe