Renowned for her iconic 90s hit "I Love You Always Forever," singer Donna Lewis planned to celebrate the 25th anniversary of her chart-topping song when life threw her an unexpected and daunting challenge. In 2021, amidst the global turmoil caused by the COVID-19 pandemic, Lewis missed her regular mammogram—a crucial oversight that would soon lead to a shocking diagnosis of breast cancer. In a candid conversation with PEOPLE, Lewis shared her journey of diagnosis and treatment, and how her love for music played a pivotal role in her recovery.
The Shocking Diagnosis: A Sudden Turn
At the age of 64, Donna Lewis received a diagnosis that she had never anticipated: stage 2A HER2-positive breast cancer. From her home in New York, Lewis recounted her disbelief upon hearing the news. “I felt fine. No lumps, no symptoms, nothing that hinted at cancer,” she revealed. The missed mammogram during the pandemic had delayed her diagnosis, causing her not only physical distress but also a profound sense of guilt. When she finally underwent the overdue mammogram, the results confirmed her worst fears. The subsequent ultrasounds and biopsies revealed two tumours, setting her on a path of intensive treatment at the renowned Memorial Sloan Kettering Cancer Center.
The Battle Against HER2-Positive Breast Cancer
HER2-positive breast cancer is known for its aggressive nature. The condition is characterised by an overexpression of the HER2 protein, which promotes the growth and spread of cancer cells. HER2, or human epidermal growth factor receptor 2, is a protein that plays a crucial role in the regulation of cell growth. In HER2-positive breast cancer, mutations cause an excessive number of HER2 proteins, leading to rapid and uncontrolled cell division.
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Symptoms and Risk Factors
As per Dr Shishir N. Shetty, Senior Consultant-Surgical Oncology, Fortis Hiranandani Hospital Vashi, HER2-positive breast cancer, like many other types of breast cancer, may not present obvious symptoms initially. When symptoms do appear, they often include changes in the size, shape, or contour of the breast, the presence of a lump, thickening of breast tissue, skin changes on the breast or nipple, and unusual discharge from the nipple. Risk factors for developing HER2-positive breast cancer include genetic mutations (such as BRCA1 or BRCA2), a personal history of breast cancer, early onset of menstruation, late onset of menopause, hormone replacement therapy, excessive alcohol consumption, and a history of radiation therapy.
The Diagnosis Process
Diagnosis of HER2-positive breast cancer involves a series of tests, including breast biopsies, which are essential for detecting cancer cells. Pathologists use immunohistochemistry (IHC) tests to look for HER2 proteins in cancer cells, and fluorescence in situ hybridisation (FISH) tests to confirm the IHC results. These tests determine the level of HER2 proteins or the number of HER2 genes in the cells, categorising the cancer as either HER2-positive or HER2-negative based on the results.
Treatment and Challenges
Treatment for HER2-positive breast cancer is multi-faceted and depends on various factors, including the stage of cancer and the specific HER2 status. Common treatments include targeted therapy, such as monoclonal antibody therapy, tyrosine kinase inhibitors, and antibody-drug conjugates. Chemotherapy is often used to shrink tumours before surgery. However, these treatments come with significant side effects, ranging from fatigue and nausea to more severe impacts on daily life. Lewis's treatment journey was arduous, involving chemotherapy, surgery, and radiation, but she remained resilient, finding solace and strength in her music.
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The Importance of Vigilance and Early Detection
Lewis's experience underscores the critical importance of regular screenings and early detection in effectively managing breast cancer. Missing her mammogram during the pandemic resulted in a delayed diagnosis and a more complex treatment path. She emphasises the necessity for women to stay vigilant about their health screenings, even amidst global disruptions.
Bottomline
Donna Lewis’s battle with breast cancer highlights not only the personal challenges she faced but also raises awareness about HER2-positive breast cancer. Her story serves as a powerful reminder of the importance of early detection and the advancements in treatment that offer hope to those diagnosed with this aggressive cancer. Through her journey, Lewis continues to inspire others with her resilience and her unwavering passion for music.