In a remarkable scientific breakthrough, researchers at the University of Pennsylvania have created a chewing gum that could significantly curb the spread of two of the world’s most prevalent viral infections — influenza and herpes. The gum, infused with natural antiviral compounds, has demonstrated the ability to destroy over 95% of viral particles in laboratory tests, raising hopes for a revolutionary method of protection that’s as simple as chewing.
A New Frontline in Viral Defense
Influenza and herpes simplex viruses (HSV) continue to pose major global health threats. Seasonal flu leads to countless hospitalisations and deaths annually, while herpes simplex virus type 1 (HSV-1) infects around 67% of the global population. Current prevention measures, including flu vaccines and antiviral medications, have shown limitations due to low uptake or lack of effective vaccines in the case of herpes.
With this in mind, scientists turned their attention to the mouth — the initial site of infection for both viruses. The idea was simple yet powerful: if viruses enter and replicate in the oral cavity, why not develop a defense mechanism right at the source?
Nature-Powered Solution from Lablab Beans
The research team, led by Professor Henry Daniell from the University of Pennsylvania’s School of Dental Medicine, found their answer in Lablab purpureus — commonly known as lablab beans. These beans naturally produce a protein called FRIL (fructose-binding lectin), which has a unique ability to bind to and neutralise viral particles.
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To harness this capability, the team processed the beans into a fine powder and incorporated it into a specially formulated chewing gum. Each gum tablet, weighing just two grams and containing 40 milligrams of the antiviral bean powder, proved capable of significantly lowering viral loads of two major flu strains (H1N1 and H3N2) and both HSV-1 and HSV-2 in controlled lab conditions.
Over 95% Viral Reduction in Lab Tests
The results were striking. When tested, the gum reduced viral presence by over 95%, suggesting powerful antiviral activity right where it’s most needed — in the mouth. The gum slowly releases the FRIL protein as it's chewed, allowing the antiviral effects to take place exactly where viruses attempt to enter the body.
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“This chewing gum has shown tremendous potential in neutralising viruses responsible for respiratory and oral infections,” said Professor Daniell. “Our results indicate that it could serve as a simple, affordable, and accessible tool for reducing viral transmission.”
Safety and Future Prospects
Importantly, the gum has been prepared according to US FDA drug safety standards, paving the way for future human trials. The researchers are now preparing for clinical testing to determine its efficacy outside the lab, particularly among individuals most at risk of transmitting or contracting these viruses.
Given its plant-based origins and food-grade formulation, the gum also represents a natural and user-friendly approach to viral control — a significant step forward in the global effort to combat infectious diseases.
A Potential Weapon Against Bird Flu
The team is also investigating the gum’s potential effectiveness against avian influenza, or bird flu, a virus that has been making headlines due to recent outbreaks in North America. If successful, the gum could become a versatile antiviral tool capable of targeting a range of viruses, both human and animal.
“Controlling viral spread remains one of the most pressing challenges in public health,” Professor Daniell noted. “Our work shows that naturally derived antiviral agents can offer a practical and impactful way forward.” As scientists move toward clinical trials, the idea of fighting viruses with something as simple as chewing gum could soon become a reality, transforming everyday habits into powerful acts of disease prevention.