The emergence of the COVID-19 'FLiRT' variants has raised concerns about their ability to bypass the immune defences provided by vaccines. Recent reports suggest that the FLiRT variant may be capable of infiltrating the immune system, attributed to a trans substitution of amino acids within two spike proteins. This genetic alteration has sparked discussions among experts regarding the potential implications for vaccine efficacy.
Can FLiRT Variant Escape Vaccine Immunity?
In the United States, alongside the FLiRT variant, two additional variants, namely KP.2 and KP.1.1, have been identified and linked to ongoing infections. The nomenclature of these variants stems from their distinctive mutations in their genetic sequences, as outlined by the Infectious Disease Society of America of the Centers for Disease Control and Prevention (CDC).
As per CDC, the nomenclature 'FLiRT' originates from technical names denoting the mutations within the virus, incorporating letters like F, L, R, and T. Among these variants, KP.2 is of particular concern, accounting for approximately 25% of newly sequenced cases across the US over the past two weeks.
Regarding the new variant ‘FLiRT’ and its impact on immune evasion, experts have noted that the mutations in the spike protein of the FLiRT variant facilitate partial evasion of the immune system's defences. This poses challenges for individuals who have received vaccinations or previously contracted COVID-19, potentially increasing susceptibility to infection.
Regarding the effectiveness of vaccines against the FLiRT variant, experts emphasised that while the variant may pose challenges, vaccines continue to offer substantial protection against severe illness, hospitalisation, and mortality associated with COVID-19.
Studies indicate that although vaccines may not entirely prevent infection, they significantly reduce viral loads, leading to milder symptoms and lower transmission rates among vaccinated individuals.
Also Read: New COVID Variant FLiRT Circulating In US, Here's What Experts Are Saying
So Should You Be Worried About The New Variant?
As per reports, the FLiRT variant is swiftly supplanting the previous Eris variant in several countries, including the US, the UK, New Zealand, and South Korea. Although the variants KP.2 and KP 1.1, noted for their increased infectiousness compared to earlier Omicron variants, are causing apprehension among health authorities, experts indicate that the symptoms associated with these variants remain consistent.
Here are the symptoms that health experts have been noticing:
- Flu-like symptoms
- Body aches
- Loss of smell and taste
- Sore throat
- Congestion
- Runny nose
- Vomiting
- Diarrhoea
- Fever
- Cough
- Breathlessness
- Fatigue
- Digestive issues
Regarding India's concerns, experts note that while the FLiRT variant has not led to a surge in hospitalisations or increased mortality rates significantly, vigilance and adherence to preventive measures are essential. These measures include vaccination, staying home when unwell, wearing masks in public, maintaining distance or avoiding crowded settings to mitigate the potential impact of this variant's spread, particularly as summer approaches and infections may rise.