Neuron Activation can Control Obesity by Curbing Appetite: Study

By  ,  Onlymyhealth editorial team
Aug 04, 2014

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Obesity ControlA new study revealed that discovering a simple switch in the brain will allow you to eat whatever you wish to and yet stay slim. The researchers have recently found that weight gain prevention is not as difficult as we think it to be. In fact, obesity, diabetes, and excessive weight gain prevention is as easy as protecting a nuclear receptor from being activated in a small part of the brain, claim the researchers.

In the research performed at Yale School of Medicine the effects of the nuclear receptor PPARgamma in small number of brain cells in mice were blocked. As a result of this, the mice ate less and became resistant to high-fat diet.
Lead author of the study, Sabrina Diano who is the professor on the Department of Obstetrics Gynecology & Reproductive Sciences at Yale School of Medicine said "these animals ate fat and sugar, and did not gain weight, while their control littermates did".

She added "we showed that the PPARgamma receptor in neurons that produce POMC could control responses to a high-fat diet without resulting in obesity".

POMC are the neurons found in the hypothalamus which regulate the food intake. When these neurons get activated they make you feel full and limit your appetite. PPARgamma is responsible for regulating the activation of these neurons.

Diano along with her team of researchers studied transgenic mice that were genetically programmed to remove the PPARgamma receptor from PMOC neurons. The researchers wished to see if obesity associated with high fat and high sugar diet could be prevented.

Diano Said "when we blocked PPARgamma in these hypothalamic cells, we found an increased level of free radical formation in POMC neurons, and they were more active".

The findings were published in The Journal of Clinical Investigation (JCI).

Image courtesy: Getty Images

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