Red wine has been used since ancient times as far back as 8000 years back. It is hastily earning recognition for bestowing health benefits if taken in moderation i.e. a glass or two a day. Found in grapes, blueberries, cranberries, mulberries, peanuts and pistachios, resveratrol is associated with beneficial health effects in aging, inflammation and metabolism.
It has been much in the news as the component of red wine associated with reducing “bad cholesterol,” heart disease and some types of cancer.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now found that resveratrol controls the body’s inflammatory response as a binding partner with the estrogen receptor without stimulating estrogenic cell proliferation, which is good news for its possible use as a model for drug design.
It does so with the help of one of the molecular pathways that it uses to achieve its beneficial action.
“Estrogen has beneficial effects on conditions like diabetes and obesity but may increase cancer risk,” said Kendall Nettles, a TSRI associate professor who led the study. “What hasn’t been well understood until now is that you can achieve those same beneficial effects with something like resveratrol.”
The problem with resveratrol, Nettles said, is that it really doesn’t work very efficiently in the body. “Now that we understand that we can do this through the estrogen receptor, there might compounds other than resveratrol out there that can do the same thing—only better,” he said.
“Our findings should lead scientists to reconsider the estrogen receptor as a main target of resveratrol—and any analogues,” said Jerome C. Nwachukwu, the first author of the study and a research associates in the Nettles laboratory. “It has gotten swept under the rug.”
In the new study, Nettles, Jerome C. Nwachukwu, the first author of the study and a research associates in the Nettles laboratory, and their colleagues found that resveratrol is an effective inhibitor of interleukin 6 (IL-6), a pro-inflammatory protein that is part of the immune system (although IL-6 can be anti-inflammatory during exercise). High levels of IL-6 are also associated with poor breast cancer patient survival.
According to the study, resveratrol regulates IL-6 without stimulating cell proliferation by altering a number of co-regulators of the estrogen receptor.
The study has been published in the online journal eLife.
Drink Red wine in moderation to improve:
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