The Menetrier disease is a rare disorder causing the ridges along the inside of the stomach wall to enrage forming gastric folds. It is also known as hypoproteinemic hypertrophic gastropathy.
The name menetrier disease is commonly used as a synonym for giant hypertrophic gastritis, however the menetrier disease is not a form of gastritis. The disease usually causes less significant symptoms that can be easily confused for symptoms from some other problem.
The condition, usually painful, occurs from overgrowth of mucous cells in the mucous membrane in the stomach resulting in giant gastric folds in the stomach lining. The enlarged stomach walls in menetrier disease cause the mucous cells to release too much mucous resulting in the protein from the blood to leak into the stomach.
The leakage of protein causes shortage of protein in the blood leading to hypoprotienemia. However, the uncontrolled hypertrophy may transform to complications and the patients need to be frequently monitored.
Menetrier disease also reduces the number of acid-producing cells in the stomach, thereby decreasing the stomach acid.
Researches suggest that men are more at risk for developing menetrier disease than women. The disease is also more common in people who are in 50s with an average diagnosis age of 55. The disease is usually self limited in children.
The most significant symptom associated with Menetrier disease is mild to severe pain in the upper middle region of the stomach. Other common symptoms of Menetrier disease are diarrhea, nausea, frequent vomiting, loss of appetite and hypoprotienemia. People with menetrier disease may also have higher chances of getting stomach cancer.
Recent studies suggest people with Menetrier disease have stomachs that make abnormally high amounts of transforming growth factor alpha, a protein that signals cells about their functioning.
The disease is diagnosed through x rays, endoscopy, and biopsy of stomach tissues and the treatment for Menetrier disease may include medications to relieve nausea and pain and surgery to remove part or all of the stomach.
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