Man Loses Noses Following Fatal Fungal Infection Due To Autoimmune Disorder: Here’s What Is Aplastic Anaemia

Aplastic anaemia is a rare blood condition in which your bone marrow fails to produce enough blood ceels, severely compromising immunity.
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Man Loses Noses Following Fatal Fungal Infection Due To Autoimmune Disorder: Here’s What Is Aplastic Anaemia


Brandon Boothby, a 31-year-old resident of Florida, United States, found himself grappling with an exceptionally rare medical condition that ultimately necessitated the removal of his nose. The ordeal commenced when he began experiencing symptoms resembling the flu, which progressively worsened, leading to a state of weakness so severe that he started fainting.

Upon seeking medical attention, tests revealed that Boothby was contending with severe aplastic anaemia, an autoimmune disorder causing his body to produce an insufficient quantity of new blood cells. This left him with compromised immunity, making him susceptible to serious infections. 

According to the National Heart, Lung, and Blood Institute, aplastic anaemia is a rare blood condition in which your bone marrow fails to produce enough red blood cells, white blood cells, and platelets. This condition can be quite serious, and for now, there is no way to prevent this disease.

What Is Aplastic Anaemia, Autoimmune Disorder That Caused US Man To Lose His Nose

Man Diagnosed WIth Aplastic Anaemia

Boothby’s health took a harrowing turn when a fungal infection seized his nasal cavity, progressively devouring his facial tissue. The severity of the situation became apparent as medical professionals warned that the infection was mere weeks away from infiltrating vital areas like his brain and eyes. 

Faced with the urgency of the situation, Boothby had no choice but to undergo the removal of his nose to prevent the infection's lethal progression. He vividly recalls the gravity of the situation, stating that if the procedure hadn't been undertaken, the infection would have reached his eyes within weeks and his brain within a month.

Post-surgery, Boothby faced the challenge of recuperating while waiting for a life-saving bone marrow transplant. According to an overview authored by researchers from East Tennessee State University, the major ways of testing aplastic anaemia are:

  • Blood and bone marrow transplants
  • Blood transfusions
  • Immunosuppressant medicines that stop the immune system from destroying bone marrow stem cells
  • Medicines that can aid the production of new blood cells
  • Removing or staying away from agents that can cause aplastic anemia
What Is Aplastic Anaemia, Autoimmune Disorder That Caused US Man To Lose His Nose

Aplastic Anemia Paving The Way For Infections

Despite returning home to his daughter and wife, Boothby’s health complications persisted. A fever prompted a return to the hospital, where he received the alarming diagnosis of a potentially fatal fungal infection. Subsequent surgeries aimed to combat the spreading fungus by addressing the pain and swelling in his nose and face.

Despite efforts to thwart the infection's advance, Boothby's journey took another perilous turn with the development of graft versus host syndrome after the bone marrow transplant. A study published in the National Library of Medicine shared that graft versus host syndrome occurs when following a transplant, the body’s immune system starts attacking the transplant. This condition resulted in extreme malnourishment, eczema-like symptoms, and inflammation of Boothy’s organs. 

Also Read: Symptoms Of The Rare 'Flesh-Eating STI' Called Donovanosis

Fortunately, owing to his pre-existing fitness, doctors opted for a natural healing approach, enabling Boothby to overcome the complications. Now, nearly two years into his recovery, he remains optimistic about the progress. Boothby emphasises the transformative impact of the experience, expressing gratitude for even the simplest pleasures in life. Having returned to full-time duty as a firefighter, he is determined to share his story as a testament to resilience and to raise awareness about the rare conditions he faced.

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