Aicardi syndrome is a rare genetic disorder that primarily affects newborn girls. The condition is sporadic, meaning it is not known to pass from parent to child. (An exception is a report of two sisters and a pair of identical twins, all of whom were affected.)
The mutation that causes Aicardi syndrome has not been identified. Scientists believe that the gene associated with the condition is located on the X chromosome because nearly all affected individuals are female and the only reports of boys having Aicardi syndrome are in boys born with an extra "X" chromosome. (Females have two X chromosomes, while males normally have an X and a Y chromosome.) Girls with Aicardi syndrome often develop seizures prior to three months and most before one year of age.
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