Men Inherit Heart Disease from Fathers

By  ,  Onlymyhealth editorial team
Feb 24, 2012

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Heart diseasesThe probability of transmitting heart diseases to the successors is almost 50%, as Male Chromosomes (Y) is passed on from one generation to the next. The research came up with the conclusion that men are more vulnerable to acquire heart ailments from their father. A breakthrough find in the sphere of genetics classify heart disease risk to the male Y chromosome. Earlier researches and findings ruled out role of Y chromosome in inheritance and conferring male sex attributes.

Lisa Bloomer, third-year PhD student in the department of cardiovascular sciences at the University of Leicester in the U.K came up with the vital findings, which will change the outlook towards genetics and importance sex chromosomes.

Team of researchers arrived at the conclusion that men who developed heart disease were more likely to acquire in ancestry. The team monitored 11 regions on the Y chromosome owing to the fact that there were no substantial changes in the chromosome overtime. In terms of genetics, people with shared ancestry belong to the same haplogroup. People of different background were compared, wherein risk for heart disease was 50% in haplogroup I (same haplogroup). Among other traditional risk factors considered were high blood pressure, cholesterol, smoking, diabetes and obesity, which did not cause the same vulnerability.

Among all groups, Haplogroup I was the third most powerful predictor after HDL and cholesterol levels to ascertain that men would develop heart disease. It is estimated that percentage of men belonging to haplogroup I is 20 in Europe and 10 in the U.S. The pattern was quite evident in northern nations of Europe, which include Denmark, Norway and Sweden.

Taking another stride in the sphere, researchers also studied the activity of certain blood cells between ancestral groups. They reached at a conclusion that genes related to the development of atherosclerosis and hardening of the arteries were prominent in the haplogroup I category. There were few differences in inflammation and immune function. In this manner, family history is one of the detriments of chances of heart disease risk among men.



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