Scleroderma, connective tissue disorder is an autoimmune disorder which could lead to various kind of skin disorder. There is a very interesting relationship between Scleroderma and Depression. It has been observed that nearly fifty percent i.e. half of the people who are suffering from Scleroderma also suffers from Scleroderma. Changes in the neurotransmitter, due to this disease aggravate depression. Apart from this, the auto immune disorder leaves the person distressed and scared therefore Scleroderma starts causing depressive symptoms in quite few people.To know more on the relationship between Scleroderma and Depression watch this video.