An inherited condition that destroys the protective coating of nerve cells present in the brain and in the entire nervous system is known as Krabbe disease. In majority cases, the signs and symptoms of Krabbe diseases develop in infants before 6 months of age and the condition usually causes death by the age 2. When the condition develops in older children and adults, its course varies largely.
Although there has been no cure for Krabbe disease, the treatment is focused on giving some supportive care. However, the stem cell transplants have shown some success in infants who undergo a treatment before the onset of symptoms and in some older children and adults.
The gene mutation which is linked with Krabbe disease only causes the disease when two mutated copies of the gene are inherited. When a disease results from two mutated copies it is called an autosomal recessive disorder. If each parent has one mutated copy of the gene, the child’s risk will be as follows:
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