Goodpasture’s syndrome can be treated with the help of oral immunosuppressive drugs—cyclophosphamide and corticosteroids. The treatment approaches keep the immune system from making antibodies.
Goodpasture’s syndrome, also referred to as glomerular basement antibody disease, is a rare condition that affects the lungs and kidneys. The autoimmune disease makes body’s own defence system reacts against some part of the body itself.
The condition affects the lungs and can be life-threatening. If the disease affects the kidneys, it may cause burning sensation during urination, blood in the urine or foamy urine and swelling of the hands and feet. Among other goodpasture’s syndrome are back pain below the ribs and high blood pressure.
Goodpasture’s syndrome is treated with oral immunosuppressive drugs—cyclophosphamide and corticosteroids—to keep the immune system from making antibodies. Corticosteroid drugs may be given intravenously to control bleeding in the lungs. A process called plasmapheresis may be helpful and necessary to remove the harmful antibodies from the blood. In plasmapheresis, a patient’s blood is drawn, about 300 ml at a time, and placed in a centrifuge to separate the red and white blood cells from the plasma. The cells are then placed in a plasma substitute and returned to the body. This procedure is usually done in combination with immunosuppressive drug treatment.
Goodpasture’s syndrome may last only a few weeks or as long as 2 years. Bleeding in the lungs can be very serious and even fatal in some cases. But Goodpasture’s syndrome does not usually lead to permanent lung damage. Damage to the kidneys, however, may be long-lasting. If the kidneys fail, dialysis to remove waste products and extra fluid from the blood, or kidney transplantation, may become necessary.
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