What are the symptoms of Menetrier Disease?

By  ,  Onlymyhealth editorial team
Jul 31, 2014
Quick Bites

  • Menetrier disease is a form of gastropathy.
  • It is not a form of gastritis.
  • Caused lack of protein in blood.
  • Involves large gastric folds.

The Menetrier disease is a rare disorder causing the ridges along the inside of the stomach wall to enrage forming gastric folds. The disease usually causes less significant symptoms that can be easily confused for symptoms from some other problem. Although, the name menetrier disease is commonly used as a synonym for giant hypertrophic gastritis, however the disease is not a form of gastritis. In order to better understand the symptoms of Menetrier disease it is important to know more about the disease.

menetrier disease

What is Menetrier disease?

Menetrier disease also known as hypoproteinemic hypertrophic gastropathy is a disorder involving overgrowth, usually massive overgrowth, of mucous cells in the mucous membrane in the stomach. It results in giants gastric folds in the stomach lining.

The mucous cells release protein-containing mucus in a normal stomach. However in a stomach with enlarged stomach walls the mucous cells release too much mucous, causing the protein from the blood to leak into the stomach. This leakage of protein in turn results in shortage of protein in the blood causing hypoprotienemia. Moreover, the disease also affects the number of acid-producing cells in the stomach, decreasing the stomach acid.

People with large gastric folds with minimal or no stomach inflammation are usually diagnosed for Menetrier disease.  Due to the lack of stomach inflammation, the disease is also classified as a form of hyperplastic gastropathy.

The Symptoms

The main symptom associated with Menetrier disease is mild to severe pain in the upper middle region of the stomach. While the pain is usually not severe, however it can be very discomforting. The actual causes of Menetrier disease are still unknown and the disease is the center of several researches worldwide. Other common symptoms of Menetrier disease are

  •     diarrhea
  •     nausea and frequent vomiting
  •     malnutrition
  •     loss of appetite
  •     extreme weight loss
  •     hypoprotienemia


Besides these symptoms the disease may also show some signs like swelling of the face, abdomen, limbs, and feet caused due to the very low levels of protein in the blood which is very common in Menetrier disease. The leakage in the stomach causes lack of oxygen in the blood which may also results in signs of anemia due to the shortage of red blood cells. People with Menetrier disease are also at a higher risk of developing gastric cancer.

Doctors start the diagnosis of Menetrier disease on the basis of these symptoms, medical history, family history and a physical examination. They then confirm the diagnosis of Menetrier disease through a CT(computerized tomography) scan, an upper gastrointestinal endoscopy endoscopy and stomach biopsy results

Image Courtesy : Getty

Read more artilces on Menetrier Disease Signs and Symptoms

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