What are the Causes of Patent Ductus Arteriosus

The cause of patent ductus arteriosus isn't known. Genetics may play a role in causing the condition. A defect in one or more genes might prevent the ductus arteriosus from closing after birth.

Ariba Khaliq
Other DiseasesWritten by: Ariba KhaliqPublished at: Oct 11, 2012Updated at: Nov 21, 2014
What are the Causes of Patent Ductus Arteriosus

The ductus arteriosus (DA) is a normal blood vessel that connects two major arteries — the aorta and the pulmonary artery — that carry blood away from the heart in a developing foetus. But when the DA fails to close, a condition called patent (meaning "open") ductus arteriosus (PDA) results, in which oxygen-rich blood from the aorta is allowed to mix with oxygen-poor blood in the pulmonary artery.

Causes of Patent Ductus ArteriosusAs a result, too much blood flows into the lungs, which puts a strain on the heart and increases blood pressure in the pulmonary arteries.

Causes of Patent Ductus Arteriosus

As a baby develops in the womb, a vascular connection (ductus arteriosus) between two major blood vessels leading from the heart — the aorta and pulmonary artery — is a normal and necessary part of your baby's blood circulation while in the womb. The ductus arteriosus diverts blood from the lungs of the foetus while they aren't being used. The foetus receives oxygen from the mother's circulation. But, the ductus arteriosus is supposed to close within two or three days after birth once the newborn's heart adapts to life outside the womb. In premature infants, the connection often takes longer to close on its own. If the connection remains open, it's referred to as a patent ductus arteriosus.

The abnormal opening causes too much blood to circulate to the lungs and heart. If not treated, the blood pressure in the lungs may increase (pulmonary hypertension) and the heart may enlarge and weaken.

Congenital heart defects arise from problems early in the heart's development — but there's often no clear cause. Genetics and environmental factors may play a role.

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