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Who is at risk of Mucopolysaccharidoses?

By  ,  National Institute of Health
Jul 21, 2011
4.8 / 5(4 Ratings)

It is an autosomal recessive disorder, meaning that only individuals inheriting the defective gene from both parents are affected. (The exception is MPS II, or Hunter syndrome, in which the mother alone passes along the defective gene to a son.) When both people in a couple have the defective gene, each pregnancy carries with it a one in four chance that the child will be affected. The parents and siblings of an affected child may have no sign of the disorder. Unaffected siblings and select relatives of a child with one of the mucopolysaccharidoses may carry the recessive gene and could pass it to their own children.

 

In general, the following factors may increase the chance of getting or passing on a genetic disease:

  • A family history of a genetic disease.
  • Parents who are closely related or part of a distinct ethnic or geographic circle.
  • Parents who do not show disease symptoms but carry a disease gene.

The mucopolysaccharidoses are classified as lysosomal storage diseases. These are conditions in which large numbers of molecules that are normally broken down or degraded into smaller pieces by intracellular units called lysosomes accumulate in harmful amounts in the body's cells and tissues, particularly in the lysosomes.

 

 

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