Zollinger-Ellison syndrome is condition when one or more tumours are formed in the pancreas or in the upper part of small intestine. These tumours are called gastrinomas and they secrete gastrin hormone in large quantities which leads the stomach to produce acid. This acid formation causes peptic ulcers in the stomach. Although the disease rare it may take place at any age. People aged between 30 and 50 years are mostly diagnosed with syndrome.
The person suffering from the syndrome may experience the following symptoms:
Although the exact cause of the condition is yet to be known but, the sequence in which the events occur are quite clear. At the beginning of the syndrome, a tumour occurs in the pancreas, duodenum, or in the lymph nodes placed adjacent to the pancreas.
The pancreas is responsible for producing enzymes which are required for digestion o food. Also, hormones like gastrin are produced by the pancreas which prevents the stomach from producing acids.
The tumour which occurs in the syndrome is made up of cells which secrete gastrin in large amounts causing the stomach to release acids which lead to peptic ulcers.
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