ZES is a rare disorder characterized by one or more tumors in the pancreas, duodenum, or both. The tumors cause the stomach to make too much acid, leading to peptic ulcers in the duodenum. The tumors are sometimes cancerous and spread to other areas of the body.
What are the stomach, duodenum, and pancreas?
The stomach, duodenum, and pancreas are digestive organs. The stomach produces gastric acid and other digestive juices that break down food. Partially digested food moves into the duodenum and is further broken down. The duodenum is the first part of the small intestine—the tube-shaped organ between the stomach and the large intestine. The pancreas is a large gland that produces digestive juices that flow into the duodenum. The pancreas also makes hormones that are released into the bloodstream. Hormones are powerful chemicals produced by glands that control the function of cells and organs.
Tumors called gastrinomas that grow in the pancreas and duodenum cause Zollinger-Ellison syndrome.
Children who have a parent with MEN1 have a 50 percent chance of inheriting the MEN1 gene and are, therefore, also at increased risk of Zollinger Ellison Syndrome.read more
A doctor diagnoses Zollinger Ellison Syndrome by assessing symptoms and measuring stomach acid and the amount of gastrin circulating in the blood.read more