Type I is the mildest and most common form of osteogenesis imperfecta. Type I OI can have the characteristics of an invisible disorder, meaning it is not apparent to a casual observer. Nearly all cases of OI, mild or severe, are caused by a dominant genetic mutation that affects the body’s production of type 1 collagen.
Osteogenesis imperfecta affects people in several ways and may vary from person to person. The most common signs and symptoms of Type I osteogenesis imperfecta are as follows.
Some people with Type I OI are very mildly affected. They may have only a few fractures. They are of average or even above-average height; are able to walk and run; and have signs of OI that are barely noticeable, such as blue-tinted sclera or loose joints. Others may have more distinct symptoms. They may have several dozen or more fractures; sometimes use a wheelchair, walker, braces, or crutches for mobility; be somewhat smaller than the rest of their family; or require treatments such as rodding surgery.
The treatment for children with Type I OI is fracture management, healthy diet, therapy to regain strength and mobility after fractures or surgery. Many orthopaedists prefer short-term casting for fractures, followed as soon as possible by a splint or brace that can be removed for appropriate exercise. Developing healthy lifestyle habits is an important part of managing OI.
Read more articles on Type I osteogenesis imperfecta.
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Diagnosis of Type I Osteogenesis Imperfecta is based primarily on clinical signs.read more