Ménétrier's disease which is also known as hypoproteinemic hypertrophic gastropathy is rare disease named after a French physician Pierre Eugene Ménétrier's.
It is an acquired disease which occurs in the stomach and is characterised by massive gastric folds, excessive mucous production which results into protein loss and negligible acid production.
The disease occurs in people aged between 30 and 60 years. Patients suffering from it experience pain in the upper abdomen sometime followed by nausea, vomiting, loss of appetite, and weight loss.
The symptoms of Ménétrier disease in children are similar to those in adults. However, adults are at a higher risk of gastric adenocarcinoma.
Although the cause of Ménétrier disease is yet to be ascertained but, it has often been associated with infection in children and H. Pylori in adults. Also, the gastric mucosa of the patients has been seen to have an increased TGF- α.
Treatment may include medications to relieve nausea and pain. A high-protein diet is prescribed to offset the loss of protein from enlarged rugae. Part or all of the stomach may need to be removed if the disease is severe. The anticancer drug cetuximab (Erbitux) blocks the action of TGF-α and is being investigated as a promising new treatment for Ménétrier disease.
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Read more on Menetrier Disease.
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