What is Tangier disease?

By  ,  Onlymyhealth editorial team
Jan 14, 2013
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Quick Bites

  • Tangier disease is a rare inherited disorder.
  • It is characterized by a severe reduction in the amount of HDL.
  • It is sometimes described as hypolipoproteinemia.
  • Disturbances in nerve function is another common symptom.

Tangier disease is a rare inherited disorder characterized by a severe reduction in the amount of high-density lipoprotein (HDL), often referred to as "good cholesterol," in the bloodstream. High-density lipoproteins are created when a type of protein in the bloodstream, apolipoprotein A1 (apoA1), picks up cholesterol from the cells.

 

tangier disease

 

Those with Tangier disease have a greatly reduced ability to transport cholesterol out of their cells, leading to a deficiency of high-density lipoproteins in the bloodstream and the accumulation of cholesterol in many body tissues. Reduced blood levels of high-density lipoproteins is sometimes described as hypolipoproteinemia.




The symptoms of Tangier disease are as follows.

  • Slightly elevated amount of fat in the blood
  • Disturbances in nerve function
  • Enlarged, orange coloured tonsils
  • Atherosclerosis
  • Enlarged spleen
  • Enlarged liver
  • Clouding of the clear covering of the eye
  • Type 2 diabetes

 

 

 

(Image source:Gettyimages.in)

Read more articles on Tangier disease.

 

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