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What are the Symptoms of Tangier disease?

By  ,  Onlymyhealth editorial team
Nov 04, 2014
4.8 / 5(4 Ratings)
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  • Amount of fat in blood increases slightly.
  • There are disturbances in nerve function.
  • The tonsils become enlarged and orange coloured.
  • Type 2 diabetes may also occur.

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What is Tangier Disease?

An inherited condition that significantly reduces levels of high-density lipoprotein (HDL) in the blood is known as Tangier disease. The HDL is required to carry cholesterol and certain fats called phospholipids from the body’s tissues to the liver, where they are removed from the blood. HDL, which is also known as the good cholesterol, can reduce the chances of developing heart and blood vessel disease. Patients of Tangier disease have low HDL levels thus, they are at an increased risk of cardiovascular disease.

Tangier Disease Symptoms

Symptoms of Tangier Disease

The signs and symptoms of Tangier disease include:

  • Slightly elevated amount of fat in the blood Disturbances in nerve function
  • Disturbances in nerve function
  • Enlarged, orange coloured tonsils
  • Atherosclerosis
  • Enlarged spleen
  • Enlarged liver
  • Clouding of the clear covering of the eye
  • Type 2 diabetes

 

How Common is Tangier Disease?

Tangier disease is a rare condition with around 100 cases indentified in the world. Some more cases likely go undiagnosed. This condition was named after an island off the coast of Virginia where the first cases of Tangier disease were indentified.

Tangier Disease Symptoms

What are Other Names Used for Tangier Disease?

Other names used Tangier disease are:

  • A-alphalipoprotein Neuropathy
  • Alpha High Density Lipoprotein Deficiency Disease
  • Analphalipoproteinemia
  • Cholesterol thesaurismosis
  • Familial High Density Lipoprotein Deficiency Disease
  • Familial Hypoalphalipoproteinemia
  • HDL Lipoprotein Deficiency Disease
  • Lipoprotein Deficiency Disease, HDL, Familial
  • Tangier Disease Neuropathy
  • Tangier Hereditary Neuropathy

Image courtesy: Getty Images

Read more on Tangier Disease Signs and Symptoms.

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