An inherited condition that significantly reduces levels of high-density lipoprotein (HDL) in the blood is known as Tangier disease. The HDL is required to carry cholesterol and certain fats called phospholipids from the body’s tissues to the liver, where they are removed from the blood. HDL, which is also known as the good cholesterol, can reduce the chances of developing heart and blood vessel disease. Patients of Tangier disease have low HDL levels thus, they are at an increased risk of cardiovascular disease.
The signs and symptoms of Tangier disease include:
Tangier disease is a rare condition with around 100 cases indentified in the world. Some more cases likely go undiagnosed. This condition was named after an island off the coast of Virginia where the first cases of Tangier disease were indentified.
Other names used Tangier disease are:
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