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What are the Symptoms of Lissencephaly?

By  ,  Onlymyhealth editorial team
Nov 05, 2014
4.8 / 5(4 Ratings)
Quick Bites

  • Lissencephaly is a gene-linked malformation.
  • Symptoms like unusual facial appearance etc occur.
  • The condition may have relation with other conditions.
  • Lissencephaly cannot be cured.

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What is Lissencephaly?

Lissencephaly, literally meaning smooth brain, is a rare gene-linked brain malformation in which the normal convolutions in the cerebral cortex is absent and an abnormally small head occurs. Children who are born with a reduced head size at the time of birth, the condition microlissencephaly is typically diagnosed. When a defective neuronal migration during embryonic development takes place, lissencephaly occurs. In this process, the nerve cells move from their place of origin to their permanent location within the cerebral cortex gray matter.

Lissencephaly Symptoms

Symptoms of Lissencephaly

The symptoms of lissencephaly include:

  • Unusual facial appearance
  • Difficulty swallowing
  • Failure to grow
  • Muscle spasms
  • Seizures
  • Severe psychomotor retardation
  • Deformation of hands and fingers

 

Relation with Other Diseases

Lissencephaly may have a relation with other diseases also. These disease include isolated lissencephaly sequence, Miller-Dieker syndrome and Walker-Warbug syndrome. At times it can get difficult to distinguish between these conditions.

Lissencephaly Symptoms

Treatment for Lissencephaly

Although there is no cure for lissencephaly but, children can show some progress in development over time. Care may be needed to comfort, feed and nurse the needs of the patient. Seizures can be troublesome but, anticonvulsant medications can be useful.

Prognosis for Lissencephaly

The prognosis for children suffering from lissencephaly depends on the degree of malformation. Many children die before the age of 10 years. Usually, the death is caused by aspiration of food or fluids, respiratory disease or severe seizures.

Image courtesy: Getty Images

Read more on Lissencephaly Signs and Symptoms.

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