CADASIL is characterized by migraine headaches and multiple strokes progressing to dementia. Other symptoms include white matter lesions throughout the brain, cognitive deterioration, seizures, vision problems, and psychiatric problems such as severe depression and changes in behavior and personality. Individuals may also be at higher risk of heart attack. Symptoms and disease onset vary widely, with signs typically appearing in the mid-30s. Some individuals may not show signs of the disease until later in life. CADASIL — formerly known by several names, including hereditary multi-infarct dementia — is one cause of multi-infarct dementia (dementia caused by lack of blood to several areas of the brain). It is an autosomal dominant inheritance disorder, meaning that one parent carries and passes on the defective gene. Most individuals with CADASIL have a family history of the disorder.
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Cerebral autosomal dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy (CADASIL) is a genetic cerebrovascular disease that occurs when the thickening of blood vessel walls blocks the flow of blood to the brain.read more
Cadasil is an inherited form of cerebrovascular disease which occurs when the blood to brain is blocked due to the thickening of the blood vessels.read more