Certain genetic changes may increase the risk of atypical teratoid/rhabdoid tumor.
Atypical teratoid/rhabdoid tumor may be linked to a change in a tumor suppressor gene called INI1. This type of gene makes a protein that helps control cell growth. Changes in the DNA of tumor suppressor genes like INI1 may lead to cancer.
Changes in the INI1 gene may be inherited (passed on from parents to offspring). When the INI1 gene change is inherited, tumors may form in two parts of the body at the same time (for example, in the brain and the kidney). If AT/RT is diagnosed, genetic counseling (a discussion with a trained professional about inherited diseases and a possible need for gene testing) may be recommended.
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