What research has been conducted on Lissencephaly?

By  ,  Onlymyhealth editorial team
Jul 27, 2011

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Quick Bites

  • Lissencephaly is a rare, gene linked malformation of the brain.
  • The normal convolutions in the cerebral cortex are absent.
  • It is characterised by an abnormally small head.
  • Researches have identified the genes responsible for it.

Lissencephaly is a rare, gene linked malformation of the brain in which the normal convolutions in the cerebral cortex are missing and is characterised by an abnormally small head.  Children with usual condition of lissencephaly have normal sized head at birth while the reduced size of head occurs in micorlissencephaly.

Lissencephaly is a rare condition


It occurs due to the migration of defective neuronal during embryonic development. It involves transportation of nerve cells to their permanent position from their place of origin.

Symptoms of the Lissencephaly

Some common symptoms of this condition include:

  • Unusual facial appearance
  • Difficulty in swallowing
  • Failure to thrive
  • Muscle Spasms
  • Seizures
  • Psychomotor retardation
  • deformed hands, finger or toes
    Treatment for Lissencephaly


Although there is no cure for lissencephaly, but the children may show progress in development over time.  Supportive care should be given to provide comfort and help in feeding and other needs.  Seizure may cause problems but anticonvulsant medications may provide relief.


Recent researches on lissencephaly have identified the genes which are responsible for this condition. These researches have laid the foundation for developing effective treatment and measures for neuronal migration disorder.


Image Courtesy: Getty

Read more article on Understand Lissencephaly

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