Early diagnosis and treatment are crucial to preserving vision and preserving life. The outlook depends on how much the cancer has grown in and beyond the eye. Over the past 20 years, earlier detection and improved treatment methods have greatly enhanced the chances of maintaining vision and have increased the survival rate. The American Cancer Society estimates that more than 90% of children treated for retinoblastoma survive more than five years. Children who still are cancer-free five years after diagnosis and treatment are generally considered cured. However, if left untreated, retinoblastoma is almost always fatal. Survivors have an increased risk of developing a second, unrelated cancer and need close follow-up.

