What is the prognosis of Megalencephaly?

By  ,  Onlymyhealth editorial team
Oct 10, 2012

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Quick Bites

  • In megalencephaly, the brain develops abnormally large and heavy.
  • It usually happens with the disturbance in the regulation of cell production in the brain.
  • No standard treatment is available for this condition.
  • The prognosis depends upon the underlying cause.

Megalencephaly is a condition in which the infant is has abnormally large and heavy brain. A megalencephalic brain weighs more than 1,600 grams while the weight of a normal average adult brain ranges between 1300 and 1400 grams. The enlargement of the head may be evident from the birth or it develops over time.


Types of Megalencephaly

  • Primary Megalencephaly
  • Secondary Megalencephaly
  • Unilateral Megalencephaly


Causes of Megalencephaly

The cause of megalencephaly is related with the disturbance in the regulation of cell production in the brain. Normally the correct number of cells is made in the right place of the brain and at the right time. Megalencephaly occurs when the brain produces too many new cells or cells which are too large in size. The abnormal collection of metabolic by products and matter can also lead to the megalencephaly.

The genetic factors that can lead also lead to this condition include:

  • Alexander Disease
  • Neurofibromatosis
  • Tuberous Sclerosis
  • Overgrowth Disorders like Sotos syndrome and Beckwith- Wiedemann Syndrome
  • Chromosomal disorders

megalencephaly treatment

Symptoms of megalencephaly

  • Delayed development of gross motor milestones
  • seizures
  • Corticospinal Dysfunction
  • mental Retardation
  • Delayed Speech Development
  • Paralysis
  • visual Irregularities



No standard treatment is available for this condition but the treatment will depend upon the cause and its symptoms.


The prognosis depends upon the underlying cause and the associated neurological disorders causes by the condition.

Image Courtesy : Getty

Read more articles on Megalencephaly Prognosis and Diagnosis

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