Lissencephaly, literal meaning "smooth brain," is a rare, gene-linked brain malformation that is characterized by the absence of normal convolutions (folds) in the cerebral cortex and an abnormally small head (microcephaly). It is caused during embryonic development by defective neuronal migration, the process in which nerve cells move from their place of origin to their permanent location.
The symptoms of lissencephaly include:
Although there is no cure for lissencephaly but, children can show some progress in development over time. Care may be needed to comfort, feed and nurse the needs of the patient. Seizures can be troublesome but, anticonvulsant medications can be useful.
Read more articles on Lissencephaly.
The prognosis for children with lissencephaly depends on the degree of brain malformation, early diagnosis, and early therapy.read more
Because lissencephaly is characterised by severe malformation in the brain's folds, it does not really work well with treatment.read more