Incontinentia pigmenti (IP) is an inherited disorder of skin pigmentation that is also associated with abnormalities of the teeth, skeletal system, eyes, and central nervous system.
It is one of a group of gene-linked diseases known as neurocutaneous disorders. In most cases, IP is caused by mutations in a gene called NEMO (NF-kappaB essential modulator). Males are more severely affected than females. Discolored skin is caused by excessive deposits of melanin (normal skin pigment).
The skin abnormalities of Incontinentia Pigmenti usually disappear by adolescence or adulthood without treatment.read more
Incontinentia pigmenti (IP) is an inherited disorder of skin pigmentation.read more