Progressive multifocal leukoencephalophathy is a disease of the white matter of the brain which is caused by a virus infects that targets the cells responsible for the formation of the oily substance known as the myelin that helps the protects the nerve cells of the brain and spinal cord.
Majority of people carry a harmless virus called polyomarvirus JC except in those who have lowered immune defences. This rare condition occurs in people who are undergoing chronic corticosteroid or immune suppressive therapy for transplant or may occur in people who have cancer. The biological treatments for some autoimmune conditions like sclerosis, rhemumatoid arthritis and systemic lupus erthematosis activates the JC virus leading to the PML.
The condition is commonly found in people who have HIV 1 infection. According to some studies, prior to the effective antiretroviral therapy as many as 5 percent of the HIV 1 infected persons eventually develop PML. But the current treatment involves antiretroviral drugs that help in restoring the immune system function of the body allowing the patients to survive the condition.
The symptoms of the condition are very diverse as they related to the location and amount of the brain caused by the infection. Some common symptoms of the condition include:
The condition can be diagnosed by carrying out following tests:
The best available therapy for the treatment of PML is reversal of the immune deficient state. For HIV patients the treatment is done to strengthen the immune system of the HIV 1 patients.
Image Courtesy : Getty
Read more articles on Progressive Multifocal Leukoencephalopathy Diagnosis and Prognosis
Though all possible measures have been taken to ensure accuracy, reliability, timeliness and authenticity of the information; Onlymyhealth assumes no liability for the same. Using any information of this website is at the viewers’ risk. Please be informed that we are not responsible for advice/tips given by any third party in form of comments on article pages . If you have or suspect having any medical condition, kindly contact your professional health care provider.