Your doctor will need blood and urine samples to evaluate your condition.
A high level of protein in a spot urine sample may indicate nephrotic syndrome. The doctor may order a 24-hour collection of urine in order to get a more precise measurement.
Blood tests may show low levels of protein. If kidney damage is advanced, waste products such as creatinine and urea nitrogen may build up in the blood.
Once nephrotic syndrome is established, the doctor may recommend a kidney biopsy—a procedure in which tiny pieces of the kidney are removed for examination with a microscope. The biopsy may reveal the underlying disease so that the doctor can determine a course of treatment. If a person has had diabetes for some time, and the patient history and laboratory tests are consistent with diabetic nephropathy, a biopsy is rarely necessary.
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