What is the diagnosis of Mastocytosis?

By  ,  National Institute of Health
Jul 01, 2011

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Your healthcare provider can diagnose cutaneous mastocytosis by the appearance of your skin and confirm it by finding an abnormally high number of mast cells on a skin biopsy. The diagnosis of systemic mastocytosis is made when an increased number of abnormal mast cells is found during an examination of your bone marrow.

Other tests that are important in evaluating a suspected case of mastocytosis include

  • Measurement of a protein (tryptase) from mast cells in your blood
  • A search for specific genetic mutations that health experts associate with this disease


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