What are the causes of Zollinger Ellison Syndrome?

By  ,  National Institute of Health
Oct 25, 2012

Subscribe for daily wellness inspiration

Like onlymyhealth on Facebook!

ZES is caused by tumors called gastrinomas, which release the hormone gastrin.


Normally, cells in the stomach produce and control gastrin so only the right amount is released. Gastrin travels through the bloodstream to signal other cells in the stomach to release gastric acid to help break down food. Gastrinomas release abnormal amounts of gastrin, resulting in excess gastric acid in the stomach and duodenum. The excess acid eventually causes sores called peptic ulcers to form in the lining of the duodenum.


Scientists are unsure what causes the majority of gastrinomas, which appear sporadically. About 25 percent of gastrinoma cases are caused by an inherited genetic disorder called multiple endocrine neoplasia type 1 (MEN1). MEN1 can cause a variety of hormone-releasing tumors such as prolactinomas and insulinomas. Prolactinomas form in the pituitary gland in the brain and cause excess prolactin—a hormone that influences milk production, fertility, and bone strength. Insulinomas form in the pancreas and cause excess insulin—a hormone that helps control blood glucose, also called blood sugar. Signs and symptoms of MEN1 include increased hormone levels in the blood, kidney stones, diabetes, muscle weakness, and weakened bones and fractures.



Write a Review
Is it Helpful Article?YES10541 Views 0 Comment
Post a Comment

Though all possible measures have been taken to ensure accuracy, reliability, timeliness and authenticity of the information; Onlymyhealth assumes no liability for the same. Using any information of this website is at the viewers’ risk. Please be informed that we are not responsible for advice/tips given by any third party in form of comments on article pages . If you have or suspect having any medical condition, kindly contact your professional health care provider.