In a recent research at the Genetics and Epidemiology at Joslin, an unknown genetic variant has been identified, which increases the risk of coronary heart disease (CHD) in type 2 diabetic patients. According to the scientists, the finding has the potential to lead to the development of new treatments for CHD in diabetic patients.
In association with colleagues from the Harvard School of Public Health and research institutes in Italy, they conducted genome-wide analysis of 1,517 type 2 diabetic patients with CHD and 2,671 type 2 diabetic subjects without CHD. Their objective was to find out whether there were genetic determinants of CHD specific to diabetic patients. They compared the results to analyses of 737 non-diabetic participants with CHD and 1,637 non-diabetic participants without CHD.
A genetic variant in the region of the GLUL gene was found to have an association with an increased risk of CHD in type 2 diabetics.
The findings have been published in the Journal of the American Medical Association (JAMA).