The first-line treatment of tuberculosis includes a combination of drugs that are primarily used for treating tuberculosis. These first-line drugs are isoniazid, rifampin pyrazinamide, streptomycin and ethambutol. Second-line drugs for the treatment of tuberculosis are reserved for the treatment in special situations such as multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) or resistance to first-line therapy. Medications included in the second line treatment for tuberculosis are:
Drug- Para-aminosalicylic acid
Drug - Levofloxacin
The principles of second line treatment for MDR-TB and XDR-TB are mostly the same. Their treatment mandates extensive chemotherapy sessions for up to two years. Second-line drugs can cause a number of side effects as they are toxic than the standard anti-TB regimen. Some side effects include hepatitis, depression and hallucinations. Patients require long isolated hospitalisation. Second-line drugs are extremely expensive when compared with the standard TB treatment. Success of second line treatment for tuberculosis depends on various factors such as the severity of the disease and their effect on immune system.
Dosage of second line drugs for children remains same as in adults. The dosage of these drugs is based on the patient’s weight and therefore, it should be adjusted as and when the patient’s weight changes. Consult an experienced doctor to know the right treatment for drug-resistant TB.
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First line drugs for tuberculosis include drugs such as Isoniazid, Rifampin, Pyrazinamide, Ethambutol and Streptomycin.read more