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Prognosis of Wilm's Tumour

By  , Expert Content
Dec 16, 2011
4.8 / 5(4 Ratings)

Prognosis indicates the possible course and outcome of a disease i.e. the chance of recovery from it or a recurrence of cancer. Understanding the prognosis or what the future holds is important for the parents as it helps them to understand the disease and live with it better.


Some important factors that influence the prognosis and long-term survival of children with Wilms tumour are:

  • Histology of tumour (how abnormal or malignant the cancer cells appear under the microscope). Based on the appearance, Wilms tumour can be separated into two mains groups:
  1. Wilms Tumour with favourable histology.
  2. Wilms Tumour with unfavourable histology.
  • Stage of cancer (the size of the tumour, extent of involvement of kidney and spread to other organs in the body).
  • Patient factors such as the age of the child and overall health of the child at the time of diagnosis.
  • Response to treatment.
  • Child's tolerance to different therapies (medications, procedures).

While discussing your child’ prognosis, the doctor will base the facts on information obtained from studies done in many patients (hundreds or even thousands) over the years with similar type of cancer. If response to treatment is good and the cancer can be cured, prognosis is considered to be favourable or good. The prognosis is believed to be poor or unfavourable if the cancer is going to be difficult to control with treatment.


According to studies, prognosis and the 5 year survival rate of most cancers is affected by the stage of cancer. Survival rates of a cancer indicate the proportion of people with a certain type and stage of cancer, who live for a specific period of time after their diagnosis. The five-year survival rate indicates the percentage of people with the disease, who are still alive five years after diagnosis (factors such as signs or symptoms of cancer, presence or absence of disease or treatment are not considered). When the 5 year survival rate is considered, it does not mean your child will only live for 5 years.


Prognosis of Wilms Tumour: In general, prognosis of Wilms tumour is very good. It has a cure rate of more than 85 percent.  The cure rate is affected by the stage and histology of the tumour. Based on histology, the prognosis of Wilms tumour is as follows:


Prognosis of favourable Wilms Tumour

  • Stage I: 10 year relapse free survival rate is about 91% and a 10 year overall survival rate is about 96%
  • Stage II: 10 year relapse free survival rate is about 85% and a 10 year overall survival rate is about 93%
  • Stage III: 10 year relapse free survival rate is about 84% and a 4 year overall survival rate is about 89%
  • Stage IV: 10 year relapse free survival rate is about 75% and a 10 year overall survival rate is about 81%

Prognosis of Unfavorable Wilms Tumor

  • Stage I: 2 year relapse free survival rate is about 65%
  • Stage II: 2 year relapse free survival rate is about 79%
  • Stage III: 2 year relapse free survival rate is about 62%
  • Stage IV: 2 year relapse free survival rate is about 33%

Remember that prognosis is the possible outcome and prognosis; therefore, the long-term survival rate can vary greatly from child to child. Prompt medical attention and aggressive therapy can improve the prognosis. Children with Wilms tumour need a long term continued follow-up care. Your doctor is the best person to tell about the prognosis of your child.

 

 

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