Prognosis of Maturity Onset Diabetes of the young

By  , Expert Content
Jan 03, 2012

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People with MODY except for MODY 2 are at a risk of developing all the complications that occur in people with type 1 or type 2 diabetes.

Prognosis of MODY

MODY 2 accounts for approximately 10-65% of MODY and most cases are diagnosed in childhood or pregnancy. Prognosis of MODY 2 is good as most cases of MODY 2 have mild diabetes and rarely develop complications. Most patients with MODY 2 do not require any medication and can be treated with meal planning alone.

Prognosis of people with other forms of MODY is not very good. They can develop all the complications of MODY such as heart disease, kidney failure, neuropathy and blindness that occur in people with type 2 diabetes. All long-term complications of MODY can be prevented or delayed by keeping blood sugar as normal as possible.

Complications of MODY

  • Cardiovascular disease: People with MODY are at a higher risk of acquiring diseases of the heart and blood vessels. High blood glucose level, over time, promotes deposits of fatty materials on the inside of the blood vessel walls and causes the hardening of blood vessels (atherosclerosis). Diabetes makes you develop coronary artery (heart) disease, a heart attack or a stroke than a non-diabetic. Studies have shown that cardiovascular diseases (such as heart attack, stroke etc) are a major cause of death and illness in people with diabetes.
  • Diabetic neuropathy: people with diabetes are prone to develop nerve damage throughout the body. Nerve damage due to diabetes is called diabetic neuropathies. Most people with diabetes have some form of neuropathy. It has been shown to be more common among individuals who have had diabetes for at least 25 years, had issues controlling their blood glucose and have high blood pressure and cholesterol.
  • Kidney disease (diabetic nephropathy): kidney damage due to diabetes is a leading cause of renal failure in adults. Kidney damage in diabetes starts and progresses slowly. Studies have shown that diabetic nephropathy occurs more commonly in people with poor control of blood sugar and progresses more rapidly if the blood sugar is not well maintained. In the initial stages, most people do not have any symptoms, but diabetic nephropathy can result in total kidney failure and the need for dialysis or kidney transplant.
  • Eye disease (diabetic retinopathy): diabetic retinopathy (eye damage due to diabetes) is a common complication of diabetes. Diabetes can cause eye problems that can cause relentless vision loss or total loss of sight. Diabetes can cause damage or injury in the retina to the blood vessels, damage to lens (cataract –which causes the eye’s lens to become cloudy) or increase in the pressure of fluid in the eye (glaucoma); all of these can gradually progress to a total loss of vision.

All these complications in MODY like other types of diabetes can be prevented or delayed by keeping blood sugar close to normal. Your doctor can advise you regarding measures that can help to prevent long term complications and improve your prognosis.


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