According to a new study conducted by an Indian origin scientist at Icahn School of medicine, a key protein may contribute to the immune system response in speed healing, counter inflammatory, infection and autoimmune disease. The study focused on proteinases, enzymes which is involved in breaking down of proteins as part of the cellular life.
Extracellular matrix, the non cell, structural framework within tissues are targeted by Martrix metalloproteinases or MMPs. A member of this family, MMP-2 has another signalling role to the immune system according to the study. The set of cells may be shifted to become part of the immune response which speeds up the healing process in some cases while worsening the condition in others.
Researchers said that scientists may be able to leverage the new found MM-2 mechanisms to prevent the contribution of inflammatory signals to tumour growth and autoimmune diseases or to promote wound healing.
The lead investigator Nina Bhardwaj, MD, PhD, Director of Immunotherapy, Tisch Cancer Center at Mount Sinai, Professor of Medicine, Hematology and Oncology, Icahn School of Medicine at Mount Sinai said “the results show that MMP- 2 uses a multitude of mechanisms to modulate the immune system. These data provides context to how this mechanism happens and could lead to novel treatments.”
The study set alive a new hope for improved wound healing, however there is still need for more advanced research on the same.
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