In a recent discovery, researchers have found the missing component that plays an important role in the regulation of the body circadian clock. The clock is, at the cellular level, controlled by a complex network of genes as well as proteins that switch each other on and off depending on cues from the environment. Scientistshave found a new circadian clock referred to as Chrono.
This new circadian clock functions as a transcriptional repressor of negative feedback loop in the mammalian clock. Akihiro Goriki from RIKEN research institute in Japan said, "The protein Chrono binds to the regulatory region of clock genes, with its repressor function oscillating in a circadian manner. The expression of core clock genes is altered in mice lacking the Chrono gene, and the mice have longer circadian cycles".
The results of the study suggest that Chrono function as core clock repressor. The findings of the research were published in the journal PLOS Biology.
Article source: Business Standard
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