A new study revealed that the synthesis of the most active component of grape seed extract, B2G2, encourages the cell death known as apoptosis in prostate cancer cells while leaving healthy cells unharmed.
According to Alpna Tyagi, PhD, of the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, there is a similar anti-cancer activity in the past with grape seed extract (GSE), but now we know B2G2 is its most biologically active ingredient which can be synthesized in quantities that will allow us to study the detailed death mechanism in cancer cells.
Previously, the GSE’s effectiveness against cancer cells and have also shown its mechanism of action. This naturally occurring compound, GSE, is a complex mixture of polyphenols and also so far it has been unclear about the biologically active constituents of GSE against cancer cells. The group pinpointed B2G2 as the most active compound, but expensive and it takes a long time to isolate B2G2 from grape seed extract.
The study also showed anti-cancer activity of synthesized B2G2 similar in mechanism and degree to overall GSE effectiveness. The study was published in the journal Nutrition and Cancer.
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