In what is being considered a breakthrough in type II diabetes related research, researchers have found that fatty foods are the most important trigger for diabetes in adults. This research was carried out on mice and on human pancreatic cells to look at how fatty foods affect insulin production and the blood sugar monitoring systems of the body.
For the study, researchers at the University of California in collaboration with RIKEN Advanced Science Institute, Japan looked at the effect of high fat foods on the pancreatic cells of mice. Also in order to compare the results that were obtained from the experiment conducted on mice, they also looked at the effect of fatty foods on the pancreatic cells of humans suffering from type II diabetes.
Upon research it was seen that due to the presence if a high fatty diet, the proteins Foxa2and Hnf1A become less effective. These proteins are responsible for the production of GnT-4a and Slc2a2 proteins. GnT-4a protein is responsible for the detection and insulin response of the body towards the glucose that is found in the bloodstream. Slc2a2 on the other hand is responsible for sensing the presence of glucose in the bloodstream. Therefore, with the productivity of important proteins shut down, the beta cells in the pancreas which are responsible for monitoring and regulating the glucose levels in the body cannot perform fully. This leads to the presence of excess glucose in the blood which in turn is a potential risk for type II diabetes.
Although researchers are not for sure that this is the way in which fatty foods affect the human pancreatic cells in general but they are hopeful that further research will shed light on this fact. Moreover, they are tipping this research as the starting point of further enquiry into the treatment options for type II diabetes.
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