In a latest study, the researchers warned that drinking more than three cups of coffee in a day can double a person’s chances of suffering from diabetes.
The latest research found that regular consumption of coffee can put adults, who cannot metabolize caffeine fast and experience hypertension, at a high risk of prediabetes that is the early stage of type two diabetes.
The team of Italian researchers studied 1,180 patients aged between 18 and 45 who were suffering from stage one hypertension but not diabetes.
It was found by the scientists that 87 per cent of the coffee drinkers consumed one to three cups in a day and 13 per cent drank more than that.
The study also found that 42 per cent of participants had a fast metabolisation of caffeine while 58 per cent had a slow metabolisation.
In six years, 24 per cent of the participants were diagnosed with prediabetes.
Participants who drank coffee in moderate amounts were found to be 34 per cent higher risk of developing prediabetes while heavy coffee drinkers were at 50 per cent heightened risk.
However, the risk of prediabetes related with coffee intake was found to be increased only in slow caffeine metabolisers.
Dr Lucio Mos from San Daniele Cardiology Hospital in Udine North East Italy said 'Lifestyle factors are very important for the prognosis of young people with hypertension.
'In a previous analysis of HARVEST (Hypertension and Ambulatory Recording Venetia Study) we found that coffee was a risk factor for the development of sustained hypertension and that the risk was modulated by the genetic background of the individual.
'Slow metabolisers of caffeine were at increased risk of hypertension.
'Our study shows that drinking coffee increases the risk of prediabetes in young adults with hypertension who are slow caffeine metabolisers.
'The risk is even greater if these individuals are overweight or obese, and if they are heavy drinkers of coffee.
'Slow caffeine metabolisers are exposed for a longer time to the detrimental effects of caffeine on glucose metabolism.
'Thus, the effect of coffee on prediabetes depends on two factors, the amount of daily coffee intake and the individual's genetic background.
'Young-to-middle-age people with hypertension should be aware that coffee consumption may increase their risk of developing diabetes in later life.
'Genotyping for the CYP1A2 gene polymorphism could help them to better know their risk.
'The results of the HARVEST study suggest that in patients with hypertension, caffeinated coffee should be considered a dietary risk factor for prediabetes.
'This risk applies especially to slow caffeine metabolisers and to patients who are overweight or obese.
'Our findings contradict previous epidemiologic studies that have advocated coffee consumption as a means to lower the risk of type two diabetes mellitus.'
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News source: dailymail.co.uk
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