Transplant Patients may Benefit from an Old Cancer Drug

By  , Agency News
Sep 02, 2013

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Quick Bites

  • Cancer drug Zebularine can prevent rejection of transplanted tissue.
  • The drug was developed in the US in 1960s.
  • Zebularine has the ability to subdue the reaction of the body's immune system.
  • Scientists believe that it could be used to curb body's attacks on its own tissue in autoimmune diseases

Scientists at Lund University discovered that an old cancer drug can be used to prevent rejection of transplanted tissue.

cancer drug can prevent transplant rejection   Researchers suggested the new treatment for both transplant patients and those with auto immune diseases.
"Our group was studying the effects of the old tumour drug Zebularine, developed in the US in the 1960s, and by chance we discovered that it had completely unexpected effects on the immune system," said Leif Salford, Senior Professor of Neurosurgery at the Rausing Laboratory, Lund University.

"It turned out that Zebularine has the ability to subdue the reaction of the body's immune system. This could be important in situations where tissue or organs are transplanted.

"We also think it could be used to curb the body's attacks on its own tissue in autoimmune diseases, for instance type 1 diabetes or rheumatoid arthritis," said researcher Dr Henrietta Nittby.

The study was done on diabetic rats. They were divided into two groups; one group was treated with Zebularine and the other, the control group, did not receive any treatment. The diabetic rats treated with Zebularine survived for a significantly longer period of time than the untreated ones.

"It is very interesting that we only treated them with Zebularine for two weeks, but the effects of the treatment could be observed throughout the 90-day follow-up period," Nittby said.

"The findings are very exciting and are a sign that the immune system was not just generally suppressed, but that the treatment was more targeted. Neither did we see any signs of side-effects," Nittby added.

The researchers are working extensively on further refining the treatment. The study was published in the journal PLOS ONE.


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