A recent study undertaken by Rockfellar Scientists have found a new link between changes in the vascular system and Alzheimer’s disease.
According to ANI report, the study found a plasma component normally associated with blood clotting and inflammation also is a part of Alzheimer’s disease patients.
It is not for the first the time that the link has been established, even the previous studies also pointed to the link. A researcher involved in the study, according to ANI, said that there is a lot of evidence substantiating that the exercises are a likely protective measure against Alzheimer’s. As we all are aware the exercises keep blood vessels healthy and blood flow consistent.
If the new link is established further it can lead to early diagnosis and new treatment methods to Alzheimer’s.
"We speculated that activation of Factor XII by beta-amyloid could play a role in initiating Alzheimer's. That's not something you can study in humans, so we looked at mouse models of disease to see what happens when Factor XII is knocked down." The news agency quoted a researcher part of the study.
The study, first published in the journal Blood, used a molecule that prevented the gene from making the protein to take out Factor XII. Normally, AD mice show much greater brain inflammation than healthy mice. However, AD mice whose Factor XII had been knocked down had much less inflammation than untreated AD mice and had brains that were more similar to those of healthy mice.
In addition, behavioural studies of AD mice with reduced Factor XII showed that their cognitive function improved. In one test, the mice were introduced to a maze with an escape hole. The animals learn the location of the hole by remembering visual cues around the maze, allowing them to escape through the hole on subsequent visits. Unlike normal mice, AD mice are unable to remember where the hole was located.
News Source: ANI
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